[HTML][HTML] Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors
J Pak, Y Pu, ZT Zhang, DL Hasty, XR Wu - Journal of Biological Chemistry, 2001 - ASBMB
The adherence of uropathogenic Escherichia coli to the urothelial surface, a critical first step
in the pathogenesis of urinary tract infection (UTI), is controlled by three key elements: E. coli
adhesins, host receptors, and host defense mechanisms. Although much has been learned
about E. coli adhesins and their urothelial receptors, little is known about the role of host
defense in the adherence process. Here we show that Tamm-Horsfall protein (THP) is the
principal urinary protein that binds specifically to type 1 fimbriated E. coli, the main cause of …
in the pathogenesis of urinary tract infection (UTI), is controlled by three key elements: E. coli
adhesins, host receptors, and host defense mechanisms. Although much has been learned
about E. coli adhesins and their urothelial receptors, little is known about the role of host
defense in the adherence process. Here we show that Tamm-Horsfall protein (THP) is the
principal urinary protein that binds specifically to type 1 fimbriated E. coli, the main cause of …
