Cytopathic hypoxia: mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis
MP Fink - Critical care clinics, 2001 - Elsevier
The most common cause of death in patients with sepsis is deterioration of the function of
multiple organs. This syndrome has been called the multiple organ dysfunction syndrome
(MODS). The organs most commonly affected are the lungs, liver, and kidneys. 50 Clinically,
manifestations of MODS include arterial hypoxemia (pulmonary dysfunction), cholestatic
jaundice (hepatic dysfunction), and azotemia (renal dysfunction). Although a fatal outcome
in patients with sepsis and septic shock is virtually always accompanied by MODS, the …
multiple organs. This syndrome has been called the multiple organ dysfunction syndrome
(MODS). The organs most commonly affected are the lungs, liver, and kidneys. 50 Clinically,
manifestations of MODS include arterial hypoxemia (pulmonary dysfunction), cholestatic
jaundice (hepatic dysfunction), and azotemia (renal dysfunction). Although a fatal outcome
in patients with sepsis and septic shock is virtually always accompanied by MODS, the …