Temporal changes in myocardial endothelial nitric oxide synthase expression following human heart transplantation
NG Vejlstrup, CB Andersen, S Boesgaard… - The Journal of heart and …, 2002 - Elsevier
Background: The incidence of cardiac allograft vasculopathy increases with time after heart
transplantation. Allograft vasculopathy is associated with endothelial dysfunction and
reduced endothelium-dependent nitric oxide-mediated vascular effects. In this study,
temporal changes in endothelial nitric oxide synthase (NOS3) expression in human
myocardial biopsies were investigated during the first 3 years after heart transplantation.
Methods: In each patient (n= 7), the immunohistochemical presence of NOS3 and inducible …
transplantation. Allograft vasculopathy is associated with endothelial dysfunction and
reduced endothelium-dependent nitric oxide-mediated vascular effects. In this study,
temporal changes in endothelial nitric oxide synthase (NOS3) expression in human
myocardial biopsies were investigated during the first 3 years after heart transplantation.
Methods: In each patient (n= 7), the immunohistochemical presence of NOS3 and inducible …
