[HTML][HTML] LXR/RXR ligand activation enhances basolateral efflux of β-sitosterol in CaCo-2 cells
FJ Field, E Born, SN Mathur - Journal of lipid research, 2004 - ASBMB
To examine whether intestinal ABCA1 was responsible for the differences observed
between cholesterol and β-sitosterol absorption, ABCA1-facilitated β-sitosterol efflux was
investigated in CaCo-2 cells following liver X receptor/retinoid X receptor (LXR/RXR)
activation. Both the LXR agonist T0901317 and the natural RXR/LXR agonists 22-
hydroxycholesterol and 9-cis retinoic acid enhanced the basolateral efflux of β-sitosterol
without altering apical efflux. LXR-mediated enhanced β-sitosterol efflux occurred between 6 …
between cholesterol and β-sitosterol absorption, ABCA1-facilitated β-sitosterol efflux was
investigated in CaCo-2 cells following liver X receptor/retinoid X receptor (LXR/RXR)
activation. Both the LXR agonist T0901317 and the natural RXR/LXR agonists 22-
hydroxycholesterol and 9-cis retinoic acid enhanced the basolateral efflux of β-sitosterol
without altering apical efflux. LXR-mediated enhanced β-sitosterol efflux occurred between 6 …
