Disruption of the murine lecithin: cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I
DS Ng, OL Francone, TM Forte, JL Zhang… - Journal of Biological …, 1997 - ASBMB
Lecithin: cholesterol acyltransferase (LCAT) is the major determinant of the cholesteryl ester
(CE) content of high density lipoprotein (HDL) in plasma. The selective uptake of HDL-CE is
postulated to participate in delivery of tissue-derived cholesterol both to the liver and
steroidogenic tissues. Recent studies comparing mice with similarly low levels of HDL, due
to the absence of either of the two major HDL-associated apolipoproteins apoA-I and apoA-
II, suggest that apoA-I is crucial in modulating this process, possibly through interaction with …
(CE) content of high density lipoprotein (HDL) in plasma. The selective uptake of HDL-CE is
postulated to participate in delivery of tissue-derived cholesterol both to the liver and
steroidogenic tissues. Recent studies comparing mice with similarly low levels of HDL, due
to the absence of either of the two major HDL-associated apolipoproteins apoA-I and apoA-
II, suggest that apoA-I is crucial in modulating this process, possibly through interaction with …
