Hepatitis C Virus-Like Particles Induce Virus–Specific Humoral and Cellular Immune Responses in Mice
M Lechmann, K Murata, J Satoi, J Vergalla… - Hepatology, 2001 - journals.lww.com
We have recently described the production of hepatitis C virus-like particles (HCV–LPs) in
insect cells that resemble the putative virions. Here we evaluate the humoral and cellular
immunogenicity of the virus–like particles with or without viral p7 protein, a small viral
polypeptide that resides between the structural and nonstructural regions of the HCV
polyprotein and whose function has not been defined. Immunized BALB/c mice developed
high titers of anti–E2 antibodies and virus–specific cellular immune responses including …
insect cells that resemble the putative virions. Here we evaluate the humoral and cellular
immunogenicity of the virus–like particles with or without viral p7 protein, a small viral
polypeptide that resides between the structural and nonstructural regions of the HCV
polyprotein and whose function has not been defined. Immunized BALB/c mice developed
high titers of anti–E2 antibodies and virus–specific cellular immune responses including …