[HTML][HTML] The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?
A McMichael, T Hanke - Nature Reviews Immunology, 2002 - nature.com
A McMichael, T Hanke
Nature Reviews Immunology, 2002•nature.comThe rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte
responses is given. We argue that such vaccines will work, provided that attention is paid to
the development of memory T-cell responses that are strong and preferably activated.
Furthermore, the vaccine should match the prevailing virus clade as closely as possible.
Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be
achieved.
responses is given. We argue that such vaccines will work, provided that attention is paid to
the development of memory T-cell responses that are strong and preferably activated.
Furthermore, the vaccine should match the prevailing virus clade as closely as possible.
Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be
achieved.
Abstract
The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.
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