HIV-1 expression in chimpanzees can be activated by CD8+ cell depletion or CMV infection
BA Castro, J Homsy, E Lennette, KK Murthy… - Clinical immunology and …, 1992 - Elsevier
CD8+ cell antiviral activity and cytomegalovirus (CMV) were investigated in vivo as possible
cofactors influencing the outcome of HIV-1 infection. The role of CD8+ cell suppression of
HIV replication was evaluated by depleting CD8+ cells in two infected chimpanzees by
inoculation with monoclonal anti-CD8 antibodies. Two other infected animals were injected
with chimpanzee CMV (CCMV)-indected human fibroblasts to determine if exposure to this
virus would induce HIV replication. Treatment with anti-CD8 antibody resulted in recovery of …
cofactors influencing the outcome of HIV-1 infection. The role of CD8+ cell suppression of
HIV replication was evaluated by depleting CD8+ cells in two infected chimpanzees by
inoculation with monoclonal anti-CD8 antibodies. Two other infected animals were injected
with chimpanzee CMV (CCMV)-indected human fibroblasts to determine if exposure to this
virus would induce HIV replication. Treatment with anti-CD8 antibody resulted in recovery of …