Interrelationships among subgroups of serum lipoproteins in normal human subjects
RM Krauss, FT Lindgren, RM Ray - Clinica Chimica Acta, 1980 - Elsevier
RM Krauss, FT Lindgren, RM Ray
Clinica Chimica Acta, 1980•ElsevierAnalytic ultracentrifugation of serum lipoproteins from 80 men and 54 women aged 27–66
was used to determine if specific segments of the high density (HDL), low density (LDL) and
very low density (VLDL) lipoprotein schlieren curves could be defined so as to reveal
significant correlations among them. Differences in correlations resulted in division of LDL
into three subgroups based on flotation rate (S 0 f 0–7, 7–12, and 12–20) and division of
HDL into two subgroups (F 0 1.20 0–1.5 and 2–9). HDL of F 0 1.20 2–9 (designated HDL 2 …
was used to determine if specific segments of the high density (HDL), low density (LDL) and
very low density (VLDL) lipoprotein schlieren curves could be defined so as to reveal
significant correlations among them. Differences in correlations resulted in division of LDL
into three subgroups based on flotation rate (S 0 f 0–7, 7–12, and 12–20) and division of
HDL into two subgroups (F 0 1.20 0–1.5 and 2–9). HDL of F 0 1.20 2–9 (designated HDL 2 …
Abstract
Analytic ultracentrifugation of serum lipoproteins from 80 men and 54 women aged 27–66 was used to determine if specific segments of the high density (HDL), low density (LDL) and very low density (VLDL) lipoprotein schlieren curves could be defined so as to reveal significant correlations among them. Differences in correlations resulted in division of LDL into three subgroups based on flotation rate (S0f 0–7, 7–12, and 12–20) and division of HDL into two subgroups (F01.20 0–1.5 and 2–9).
HDL of F01.20 2–9 (designated HDL2–9) correlated negatively with LDL of S0f 0–7 (LDL0–7) for all groups, positively with LDL of S0f 7–12 except in women aged 27–46, and negatively with VLDL except in men aged 47–66, HDL of F0f 0–1.5 (HDL0–1.5) correlated positively with LDL0–7 except in men aged 27–46 and with VLDL in all but older men. Some correlations were reduced to non-significant levels by controlling for LDL0–7 or VLDL.
Correlations of HDL and LDL flotation subgroups yielded no significant net correlation between total HDL and LDL. Total HDL was directly correlated with HDL1–9 (r > 0.97) but not with HDL0–1.5. The foregoing suggests that decreased HDL represents reduced HDL2–9 and may be accompanied by increased LDL0–7 and VLDL. LDL0–7 may represent an “atherogenic” LDL subclass in part responsible for increased coronary risk associated with low HDL.
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