[HTML][HTML] The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock
F Tarantini, T LaVallee, A Jackson, S Gamble… - Journal of Biological …, 1998 - ASBMB
The heparin-binding fibroblast growth factor (FGF) prototypes lack a classical signal
sequence, yet their presence is required in the extracellular compartment for the activation of
cell-surface receptor-dependent signaling. Early studies with FGF-1 demonstrated its
presence in bovine brain as a novel high molecular weight complex, and subsequent
studies identified a second heparin-binding protein that co-purified with FGF-1. Polypeptide
sequence analysis revealed that this heparin-binding protein corresponded to the …
sequence, yet their presence is required in the extracellular compartment for the activation of
cell-surface receptor-dependent signaling. Early studies with FGF-1 demonstrated its
presence in bovine brain as a novel high molecular weight complex, and subsequent
studies identified a second heparin-binding protein that co-purified with FGF-1. Polypeptide
sequence analysis revealed that this heparin-binding protein corresponded to the …