Regional specialization in the mucosal immune system: primed cells do not always home along the same track
P Brandtzaeg, IN Farstad, G Haraldsen - Immunology today, 1999 - cell.com
P Brandtzaeg, IN Farstad, G Haraldsen
Immunology today, 1999•cell.comAccording to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate
in the intestinal lamina propria chiefly by means of the mucosal homing receptor α 4 β 7,
which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this
mechanism cannot explain the preferential homing of B cells with a high level of J-chain
expression to mucosal effector sites outside the gut.
in the intestinal lamina propria chiefly by means of the mucosal homing receptor α 4 β 7,
which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this
mechanism cannot explain the preferential homing of B cells with a high level of J-chain
expression to mucosal effector sites outside the gut.
Abstract
According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor α4β7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.
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