A novel metal-chelating inhibitor of protein farnesyltransferase
A Hamasaki, H Naka, F Tamanoi, K Umezawa… - Bioorganic & medicinal …, 2003 - Elsevier
A Hamasaki, H Naka, F Tamanoi, K Umezawa, M Otsuka
Bioorganic & medicinal chemistry letters, 2003•ElsevierA novel metal chelator comprising a 4-(naphthalen-1-yl) pyridine and 2-aminoethanethiol
was synthesized. This showed inhibitory activity against human protein farnesyltransferase
with IC50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and
showed growth inhibition of K-ras-NRK cells with IC50 0.32 μg/mL.
was synthesized. This showed inhibitory activity against human protein farnesyltransferase
with IC50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and
showed growth inhibition of K-ras-NRK cells with IC50 0.32 μg/mL.
A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and showed growth inhibition of K-ras-NRK cells with IC50 0.32 μg/mL.
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