[HTML][HTML] Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun
T Meyer-ter-Vehn, A Covacci, M Kist, HL Pahl - Journal of Biological …, 2000 - ASBMB
Helicobacter pylori is an etiological agent in the development of mucosa-associated
lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with H. pylori
carry a 3–6-fold increased risk of developing cancer compared with uninfected individuals.
H. pylori strains expressing the cytotoxin-associated antigen A (CagA) are more frequently
associated with the development of neoplasia than cagA-negative strains. However, the
molecular mechanism by whichH. pylori causes neoplastic transformation remains unclear …
lymphoid tissue lymphoma and gastric adenocarcinoma. Patients infected with H. pylori
carry a 3–6-fold increased risk of developing cancer compared with uninfected individuals.
H. pylori strains expressing the cytotoxin-associated antigen A (CagA) are more frequently
associated with the development of neoplasia than cagA-negative strains. However, the
molecular mechanism by whichH. pylori causes neoplastic transformation remains unclear …