CD28+ intraepithelial lymphocytes with long telomeres are recruited within the inflamed ileal mucosa in Crohn disease
B Meresse, S Dubucquoi, B Tourvieille… - Human Immunology, 2001 - Elsevier
Crohn disease is a chronic inflammatory bowel disease that involves all the intestine but
predominantly alters the ileum. The disease largely depends on T cells, but the biologic role
of intestinal intraepithelial lymphocytes (IEL) in transmural inflammation remains poorly
characterized. To address this issue, a comparison of IEL and lamina propria lymphocytes
(LPL) isolated from the uninvolved and the inflamed ileal mucosa of Crohn disease patients
was performed. More CD8+ IEL (26% versus 8%) from the inflamed ileal mucosa expressed …
predominantly alters the ileum. The disease largely depends on T cells, but the biologic role
of intestinal intraepithelial lymphocytes (IEL) in transmural inflammation remains poorly
characterized. To address this issue, a comparison of IEL and lamina propria lymphocytes
(LPL) isolated from the uninvolved and the inflamed ileal mucosa of Crohn disease patients
was performed. More CD8+ IEL (26% versus 8%) from the inflamed ileal mucosa expressed …