Granulation tissue formation in oophorectomized rats treated with female sex hormones. II. Studies on the amount of collagen and on tensile strength.

B Pallin, J Ahonen, B Zederfeldt - Acta Chirurgica Scandinavica, 1975 - europepmc.org
B Pallin, J Ahonen, B Zederfeldt
Acta Chirurgica Scandinavica, 1975europepmc.org
The content of hydroxyproline and tensile strength of granulation tissue was studied in
oophorectomized rats treated with female sex hormones. Estrogen alone caused a slight
decrease of hydroxyproline, but had no effect on the tensile strength of the granulation tissue
at one week. Progesterone alone or in combination with estrogen decreased the content of
hydroxyproline and the tensile strength of the granulation tissue up to one week in the case
of progesterone-treated animals and up to two weeks in the case of animals treated with the …
The content of hydroxyproline and tensile strength of granulation tissue was studied in oophorectomized rats treated with female sex hormones. Estrogen alone caused a slight decrease of hydroxyproline, but had no effect on the tensile strength of the granulation tissue at one week. Progesterone alone or in combination with estrogen decreased the content of hydroxyproline and the tensile strength of the granulation tissue up to one week in the case of progesterone-treated animals and up to two weeks in the case of animals treated with the combination of the hormones. At one week no direct correlation was found between the amount of hydroxyproline and the tensile strength of granulation tissue in oophorectomized rats treated with estrogen and progesterone in combination.
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