[HTML][HTML] Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
M Silberbach, T Gorenc, RE Hershberger… - Journal of Biological …, 1999 - ASBMB
Atrial natriuretic factor (ANF) inhibits proliferation in non-myocardial cells and is thought to
be anti-hypertrophic in cardiomyocytes. We investigated the possibility that the anti-
hypertrophic actions of ANF involved the mitogen-activated protein kinase signal
transduction cascade. Cultured neonatal rat ventricular myocytes treated for 48 h with the α
1-adrenergic agonist phenylephrine (PE) had an 80% increase in cross-sectional area
(CSA). ANF alone had no effect but inhibited PE-induced increases in CSA by approximately …
be anti-hypertrophic in cardiomyocytes. We investigated the possibility that the anti-
hypertrophic actions of ANF involved the mitogen-activated protein kinase signal
transduction cascade. Cultured neonatal rat ventricular myocytes treated for 48 h with the α
1-adrenergic agonist phenylephrine (PE) had an 80% increase in cross-sectional area
(CSA). ANF alone had no effect but inhibited PE-induced increases in CSA by approximately …