Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein.
Y Wang, J Chen, L Chen, YC Tay… - Journal of the …, 1997 - journals.lww.com
Cytokines play a pivotal role in synthesis and deposition of extracellular matrix in chronic
renal failure (CRF). The proinflammatory properties of monocyte chemoattractant protein
(MCP)-1 make it an ideal candidate cytokine for the production of interstitial inflammation in
CRF. To investigate the possible role of proteinuria in inducing proximal tubular (PT) MCP-1,
MCP-1 mRNA levels were measured by Northern blot and reverse transcription PCR in
confluent monolayers of PT cells in primary culture in media containing a variety of proteins …
renal failure (CRF). The proinflammatory properties of monocyte chemoattractant protein
(MCP)-1 make it an ideal candidate cytokine for the production of interstitial inflammation in
CRF. To investigate the possible role of proteinuria in inducing proximal tubular (PT) MCP-1,
MCP-1 mRNA levels were measured by Northern blot and reverse transcription PCR in
confluent monolayers of PT cells in primary culture in media containing a variety of proteins …