Toxicity of holotransferrin but not albumin in proximal tubule cells in primary culture.
L Chen, RA Boadle, DC Harris - Journal of the American Society of …, 1998 - journals.lww.com
Proteinuria has been invoked as a cause of tubulointerstitial injury in chronic renal disease,
and in vivo studies have suggested indirectly the particular nephrotoxicity of one urinary
protein holotransferrin (Tf-Fe). However, to date there has been no direct evidence for the
nephrotoxicity of Tf-Fe. To examine the potential cytotoxicity of Tf-Fe and the mechanism
involved, and to compare this to another urinary protein albumin, rat proximal tubule cells
were studied in primary culture. Tf-Fe at pH 6.0 caused functional and ultrastructural injury …
and in vivo studies have suggested indirectly the particular nephrotoxicity of one urinary
protein holotransferrin (Tf-Fe). However, to date there has been no direct evidence for the
nephrotoxicity of Tf-Fe. To examine the potential cytotoxicity of Tf-Fe and the mechanism
involved, and to compare this to another urinary protein albumin, rat proximal tubule cells
were studied in primary culture. Tf-Fe at pH 6.0 caused functional and ultrastructural injury …