Protein overload-induced NF-κB activation in proximal tubular cells requires H2O2 through a PKC-dependent pathway
Abnormal traffic of proteins through the glomerular capillary has an intrinsic toxicity that
results in tubular dysfunction and interstitial inflammation. It has been previously shown that
in porcine proximal tubular cells high concentrations of albumin activated NF-κB, which is
responsible for the enhanced synthesis of the inflammatory chemokine RANTES. This study
investigates whether reactive oxygen species (ROS) served as second messengers in
protein overload-induced NF-κB activation. Human proximal tubular cells (HK-2) were …
results in tubular dysfunction and interstitial inflammation. It has been previously shown that
in porcine proximal tubular cells high concentrations of albumin activated NF-κB, which is
responsible for the enhanced synthesis of the inflammatory chemokine RANTES. This study
investigates whether reactive oxygen species (ROS) served as second messengers in
protein overload-induced NF-κB activation. Human proximal tubular cells (HK-2) were …