Intraglomerular C3 synthesis in human kidney detected by in situ hybridization.
M Miyazaki, K Abe, T Koji, A Furusu… - Journal of the …, 1996 - journals.lww.com
Complements 3 and 4 are known to be synthesized in diseased renal tissue and the mRNA
of these complements has been demonstrated, using polymerase chain reaction, in renal
biopsies from nephritic patients. However, the types of cells producing the complements in
intact renal tissue have not been defined. To identify the renal cellular components involved
in complement synthesis, we analyzed the expression of C3 mRNA in renal tissues from
patients with immune-complex glomerulonephritis by a high-resolution in situ hybridization …
of these complements has been demonstrated, using polymerase chain reaction, in renal
biopsies from nephritic patients. However, the types of cells producing the complements in
intact renal tissue have not been defined. To identify the renal cellular components involved
in complement synthesis, we analyzed the expression of C3 mRNA in renal tissues from
patients with immune-complex glomerulonephritis by a high-resolution in situ hybridization …