Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells
JCK Leung, AWL Tsang, DTM Chan… - Journal of the American …, 2000 - journals.lww.com
IgA nephropathy (IgAN) is characterized by raised serum IgA and predominant mesangial
IgA deposits of polymeric nature. The expression of IgA receptor molecules in white blood
cells and glomerular mesangial cells has recently attracted much attention in relation to the
uptake of IgA by these cells. This study investigates the expression of IgA Fc receptor
(FcαR1 or CD89), asialoglycoprotein receptor (ASGPR), and polymeric Ig receptor (pIgR) in
cultured glomerular mesangial cells. Using a sensitive nested reverse transcription-PCR …
IgA deposits of polymeric nature. The expression of IgA receptor molecules in white blood
cells and glomerular mesangial cells has recently attracted much attention in relation to the
uptake of IgA by these cells. This study investigates the expression of IgA Fc receptor
(FcαR1 or CD89), asialoglycoprotein receptor (ASGPR), and polymeric Ig receptor (pIgR) in
cultured glomerular mesangial cells. Using a sensitive nested reverse transcription-PCR …