CD1-restricted T-cell responses and microbial infection
SH Park, A Bendelac - Nature, 2000 - nature.com
SH Park, A Bendelac
Nature, 2000•nature.comCD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals,
specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes.
The principles and mechanisms of this newly discovered immune strategy differ markedly
from those governing classical MHC–peptide presentation. They might be exploited for the
design of new lipid-based microbial vaccines and adjuvants.
specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes.
The principles and mechanisms of this newly discovered immune strategy differ markedly
from those governing classical MHC–peptide presentation. They might be exploited for the
design of new lipid-based microbial vaccines and adjuvants.
Abstract
CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC–peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.
nature.com