Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndrome.
A Franco, G Valesini, V Barnaba, C Silvagni… - Clinical and …, 1987 - europepmc.org
A Franco, G Valesini, V Barnaba, C Silvagni, A Tiberti, F Balsano
Clinical and Experimental Rheumatology, 1987•europepmc.orgClass II MHC molecules are two-chain glycoproteins normally expressed only on the
membrane of cells involved in the immune response. These molecules are restriction
elements for helper T cells. Using indirect immunofluorescence on cryostat sections of
biopsied salivary glands we have demonstrated epithelial expression of class II antigens in
patients with Sjögren's syndrome. The HLA DR+ epithelial cells were seen in close proximity
to lymphocyte infiltrates. The finding that class II molecules are also expressed in salivary …
membrane of cells involved in the immune response. These molecules are restriction
elements for helper T cells. Using indirect immunofluorescence on cryostat sections of
biopsied salivary glands we have demonstrated epithelial expression of class II antigens in
patients with Sjögren's syndrome. The HLA DR+ epithelial cells were seen in close proximity
to lymphocyte infiltrates. The finding that class II molecules are also expressed in salivary …
Class II MHC molecules are two-chain glycoproteins normally expressed only on the membrane of cells involved in the immune response. These molecules are restriction elements for helper T cells. Using indirect immunofluorescence on cryostat sections of biopsied salivary glands we have demonstrated epithelial expression of class II antigens in patients with Sjögren's syndrome. The HLA DR+ epithelial cells were seen in close proximity to lymphocyte infiltrates. The finding that class II molecules are also expressed in salivary glands without focal lymphocytic infiltrates suggests a" modulation" as opposed to" induction" of HLA DR antigens on epithelial cells in Sjögren's syndrome, the distinction being related to the enhancement of low levels of expressions vs. de novo synthesis.
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