The proto-oncogene Bcl-2 and its role in regulating apoptosis
G Kroemer - Nature medicine, 1997 - nature.com
Nature medicine, 1997•nature.com
regulating apoptosis Page 1 G) 1997 Nature Publishing Group http://www.nature.com/naturemedicine
REVIEW The proto-oncogene Bcl-2 and its role in regulating apoptosis The mechanism of
action of Bcl-2 provides clues for therapeutic interventions Apoptosis constitutes a strictly
regulated (programmed) device for the removal of unnecessary, aged or damaged celis. An
abnormal resistance to apoptosis induction entails malformations, autoimmune disease or
cancer due to the persistence of superfluous, self-specific or mutated cells, respectively. In …
REVIEW The proto-oncogene Bcl-2 and its role in regulating apoptosis The mechanism of
action of Bcl-2 provides clues for therapeutic interventions Apoptosis constitutes a strictly
regulated (programmed) device for the removal of unnecessary, aged or damaged celis. An
abnormal resistance to apoptosis induction entails malformations, autoimmune disease or
cancer due to the persistence of superfluous, self-specific or mutated cells, respectively. In …
Abstract
The mechanism of action of Bcl-2 provides clues for therapeutic interventions
nature.com
