[HTML][HTML] The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin
E Cocolakis, S Lemay, S Ali, JJ Lebrun - Journal of Biological Chemistry, 2001 - ASBMB
Activin, a member of the TGFβ family inhibits cell growth in various target tissues. Activin
interacts with a complex of two receptors that upon activation phosphorylate specific
intracellular mediators, the Smad proteins. The activated Smads interact with diverse DNA
binding proteins and co-activators of transcription in a cell-specific manner, thus leading to
various activin biological effects. In this study, we investigated the role and mechanism of
action of activin in the human breast cancer T47D cells. We found that activin treatment of …
interacts with a complex of two receptors that upon activation phosphorylate specific
intracellular mediators, the Smad proteins. The activated Smads interact with diverse DNA
binding proteins and co-activators of transcription in a cell-specific manner, thus leading to
various activin biological effects. In this study, we investigated the role and mechanism of
action of activin in the human breast cancer T47D cells. We found that activin treatment of …