This paper reviews recent information about neural and humoral control of arterial blood pressure. Considerable evidence is accumulating in support of the concept that neural and humoral systems interact at both central and peripheral sites to modulate arterial pressure and to participate in the mechanisms of hypertension. The neural mechanisms reviewed include reflexes originating from sinoaortic receptors, and afferents arising from the kidney. Humoral agents discussed include angiotensin and vasopressin and the participation of their central and peripheral actions in the pathogenesis of hypertension.