Inability of dendritic cells to prevent the blood transfusion effect in a mouse cardiac allograft model
WN PEUGH, JM AUSTYN, NP CARTER… - …, 1987 - journals.lww.com
WN PEUGH, JM AUSTYN, NP CARTER, KJ WooD, PJ MORRIS
Transplantation, 1987•journals.lww.comThe beneficial effect of blood transfusions before clinical renal transplantation is well
established, but this can result in sensitization of some potential first graft recipients.
Dendritic cells (DC), present in human blood, are potent stimulators of immune responses in
vitro and in vivo, and in different systems they can overcome immune unresponsiveness. We
therefore investigated whether DC could prevent the transfusion effect in a murine cardiac
allograft model.
established, but this can result in sensitization of some potential first graft recipients.
Dendritic cells (DC), present in human blood, are potent stimulators of immune responses in
vitro and in vivo, and in different systems they can overcome immune unresponsiveness. We
therefore investigated whether DC could prevent the transfusion effect in a murine cardiac
allograft model.
Abstract
The beneficial effect of blood transfusions before clinical renal transplantation is well established, but this can result in sensitization of some potential first graft recipients. Dendritic cells (DC), present in human blood, are potent stimulators of immune responses in vitro and in vivo, and in different systems they can overcome immune unresponsiveness. We therefore investigated whether DC could prevent the transfusion effect in a murine cardiac allograft model.
Lippincott Williams & Wilkins