[HTML][HTML] CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium
MN Becker, G Diamond, MW Verghese… - Journal of Biological …, 2000 - ASBMB
The induction of host antimicrobial molecules following binding of pathogen components to
pattern recognition receptors such as CD14 and the Toll-like receptors (TLRs) is a key
feature of innate immunity. The human airway epithelium is an important environmental
interface, but LPS recognition pathways have not been determined. We hypothesized that
LPS would trigger β− defensin (hBD2) mRNA in human tracheobronchial epithelial (hTBE)
cells through a CD14-dependent mechanism, ultimately activating NF-κB. An average 3-fold …
pattern recognition receptors such as CD14 and the Toll-like receptors (TLRs) is a key
feature of innate immunity. The human airway epithelium is an important environmental
interface, but LPS recognition pathways have not been determined. We hypothesized that
LPS would trigger β− defensin (hBD2) mRNA in human tracheobronchial epithelial (hTBE)
cells through a CD14-dependent mechanism, ultimately activating NF-κB. An average 3-fold …
