[HTML][HTML] p42/44 MAP kinase-dependent and-independent signaling pathways regulate caveolin-1 gene expression: activation of Ras-MAP kinase and protein kinase a …
JA Engelman, XL Zhang, B Razani, RG Pestell… - Journal of Biological …, 1999 - ASBMB
Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and
protein expression are down-regulated in NIH 3T3 cells in response to transformation by
activated oncogenes, such as H-Ras (G12V) and v-Abl. The mechanisms governing this
down-regulation event remain unknown. Here, we show that caveolin-1 gene expression is
directly regulated by activation of the Ras-p42/44 MAP kinase cascade. Down regulation of
caveolin-1 protein expression by Ras is independent of (i) the type of activating mutation …
protein expression are down-regulated in NIH 3T3 cells in response to transformation by
activated oncogenes, such as H-Ras (G12V) and v-Abl. The mechanisms governing this
down-regulation event remain unknown. Here, we show that caveolin-1 gene expression is
directly regulated by activation of the Ras-p42/44 MAP kinase cascade. Down regulation of
caveolin-1 protein expression by Ras is independent of (i) the type of activating mutation …
