Epidermal remodelling in psoriasis
H Iizuka, A Ishida‐Yamamoto… - British Journal of …, 1996 - academic.oup.com
H Iizuka, A Ishida‐Yamamoto, H Honda
British Journal of Dermatology, 1996•academic.oup.comPsoriatic hyperproliferative epidermis is characterized by a regular elongation of rete ridges,
accompanied by altered keratinization. Another notable finding is close positioning of the
vasculature to the suprapapillary epidermis. These architectural/morphological changes are
naturally described by a concept of epidermal remodelling based on decreased epidermal
turnover time. The recently described positioning of stem cells to the tips of dermal papillae
fits nicely with this concept.
accompanied by altered keratinization. Another notable finding is close positioning of the
vasculature to the suprapapillary epidermis. These architectural/morphological changes are
naturally described by a concept of epidermal remodelling based on decreased epidermal
turnover time. The recently described positioning of stem cells to the tips of dermal papillae
fits nicely with this concept.
Summary
Psoriatic hyperproliferative epidermis is characterized by a regular elongation of rete ridges, accompanied by altered keratinization. Another notable finding is close positioning of the vasculature to the suprapapillary epidermis. These architectural/morphological changes are naturally described by a concept of epidermal remodelling based on decreased epidermal turnover time. The recently described positioning of stem cells to the tips of dermal papillae fits nicely with this concept.
Oxford University Press