[HTML][HTML] Cloning of the Murine β5 Integrin Subunit Promoter: IDENTIFICATION OF A NOVEL SEQUENCE MEDIATING GRANULOCYTE-MACROPHAGE COLONY …
X Feng, SL Teitelbaum, ME Quiroz, DA Towler… - Journal of Biological …, 1999 - ASBMB
We previously noted that the initial receptor by which murine osteoclast precursors bind
matrix is the integrin α v β 5 and that granulocyte-macrophage colony-stimulating factor (GM-
CSF) decreases expression of this heterodimer by suppressing transcription of the β 5 gene.
We herein report cloning of the β 5 integrin gene promoter and identification of a GM-CSF-
responsive sequence. A 13-kilobase (kb) genomic fragment containing part of the β 5 gene
was isolated by screening a mouse genomic library with a probe derived from the most 5 …
matrix is the integrin α v β 5 and that granulocyte-macrophage colony-stimulating factor (GM-
CSF) decreases expression of this heterodimer by suppressing transcription of the β 5 gene.
We herein report cloning of the β 5 integrin gene promoter and identification of a GM-CSF-
responsive sequence. A 13-kilobase (kb) genomic fragment containing part of the β 5 gene
was isolated by screening a mouse genomic library with a probe derived from the most 5 …