DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements
C Juge-Aubry, A Pernin, T Favez, AG Burger… - Journal of Biological …, 1997 - ASBMB
The three subtypes of the peroxisome proliferator-activated receptors (PPARα, β/δ, and γ)
form heterodimers with the 9-cis-retinoic acid receptor (RXR) and bind to a common
consensus response element, which consists of a direct repeat of two hexanucleotides
spaced by one nucleotide (DR1). As a first step toward understanding the molecular
mechanisms determining PPAR subtype specificity, we evaluated by electrophoretic mobility
shift assays the binding properties of the three PPAR subtypes, in association with either …
form heterodimers with the 9-cis-retinoic acid receptor (RXR) and bind to a common
consensus response element, which consists of a direct repeat of two hexanucleotides
spaced by one nucleotide (DR1). As a first step toward understanding the molecular
mechanisms determining PPAR subtype specificity, we evaluated by electrophoretic mobility
shift assays the binding properties of the three PPAR subtypes, in association with either …
